Olink Proteomics Biomarker Profiling

The biomarker profiling using the Olink Proximity Extension Assay (PEA) enables analysing specific protein signatures to monitor disease progression, treatment responses, and drug efficacy. The PEA technology allows a multiplex analysis with a simultaneous relative quantification of 92 proteins using 1 µL of sample.

The Target 96 panels cover the disease areas inflammation, immuno-oncology, cardiovascular diseases, oncology, and neurology. Additionally, biological processes such as organ damage, metabolism, development, immune response, neuro-exploratory, cell regulation and cardio-metabolisms can be explored.

The Target 48 Cytokine and Immune Surveillance panel aim to detect biomarkers central to inflammatory responses covering major therapeutic areas. The Target 48 panels enable the absolute quantification (pg/ml) of 42 proteins.

The Olink Focus and Olink Flex allow analysing up to 21 proteins-of-interest, which can be selected from Olink's full assay library covering >3000 protein biomarkers or from about 200 biomarkers with a 99% combinability, respectively. Thereby these panels can be used to establish disease or treatment specific biomarkers allowing for example patients selection and stratification.

All assays are compatible with plasma/serum, conditioned media, cell/tissue lysates, cerebrospinal fluid (CSF), urine, interstitial fluid/microdialysis, ocular fluids, dried blood spots, exosomes, and synovial fluid.